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胡國宏

胡國宏

博士
腫瘤轉(zhuǎn)移研究組組長

郵箱: ghhu@sinh.ac.cn

電話: +86-21-54923296

所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室

個人簡歷

2017-至???今:中國科學院上海營養(yǎng)與健康研究所,研究員,院長助理,副所長(主持工作)
2009-2016年:中國科學院上海生命科學研究院/上海交通大學醫(yī)學院健康科學研究所,研究員
2014-2016年:中國科學院上海生命科學研究院/上海交通大學醫(yī)學院健康科學研究所,副所長
2011-2014年:中國科學院上海生命科學研究院/上海交通大學醫(yī)學院健康科學研究所,所長助理
2009-2009年:美國普林斯頓大學分子生物系,Associate Research Scholar
2005-2008年:美國普林斯頓大學分子生物系,博士后
2000-2005年:美國羅格斯大學,分子遺傳學,博士
1996-2000年:清華大學,生物科學與技術(shù)系,學士

研究方向

腫瘤轉(zhuǎn)移與微環(huán)境調(diào)控

研究內(nèi)容

1. 轉(zhuǎn)移的微環(huán)境調(diào)控機制。腫瘤轉(zhuǎn)移是癌癥致死的主要原因。癌細胞對其所處微環(huán)境的適應及改造對轉(zhuǎn)移過程有重要影響。我們主要研究癌細胞與轉(zhuǎn)移微環(huán)境的互作機制,以及這些互作對腫瘤轉(zhuǎn)移能力、轉(zhuǎn)移的器官特異性、癌細胞的轉(zhuǎn)移休眠/重激活狀態(tài)的調(diào)控作用,并進一步發(fā)現(xiàn)有效預測腫瘤轉(zhuǎn)移的分子標志物以及靶向腫瘤-微環(huán)境互作的策略。

2. 腫瘤干細胞與轉(zhuǎn)移。腫瘤干細胞一般被認為是癌癥發(fā)生、抗藥及復發(fā)的“元兇”,但是腫瘤干細胞與轉(zhuǎn)移的關(guān)系尚不清楚。我們主要研究腫瘤干細胞在轉(zhuǎn)移中發(fā)揮的作用及調(diào)控機制,分析腫瘤干細胞的異質(zhì)性,不同干細胞亞群的轉(zhuǎn)移及調(diào)控,腫瘤干細胞與轉(zhuǎn)移微環(huán)境的互作等,以期發(fā)現(xiàn)通過靶向腫瘤干細胞抑制轉(zhuǎn)移的方法。

3. 腫瘤代謝調(diào)控與轉(zhuǎn)移。腫瘤的Warburg效應已經(jīng)引起廣泛關(guān)注。我們主要研究在轉(zhuǎn)移過程中的糖脂代謝調(diào)控,包括癌細胞自身的代謝異常模式、代謝微環(huán)境對癌細胞轉(zhuǎn)移能力以及轉(zhuǎn)移器官特異性的調(diào)控作用等。

代表論著(#第一作者,*通訊作者)

1.?Wu Q, Tian P, He D, Jia Z, He Y, Luo W, Lv X, Wang Y, Zhang P, Liang Y, Zhao W, Qin J, Su P, Jiang YZ, Shao ZM, Yang Q*, Hu G*. SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. Cell Res 2023 Jun;33(6):464-478

2.?Wang Y, Jia Z, Liang C, He Y, Cong M, Wu Q, Tian P, He D, Miao X, Sun B, Yin Y, Peng C, Yao F, Fu D, Liang Y, Zhang P*, Xiong H*, Hu G*. MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discov 2023 Feb 21;9(1):20

3.?He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, Ma YS, Yang H, Xu K, Zhang X, Xiao Y, Zhang P, Liang Y, Fu D*, Yao F*, Hu G*. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. J Clin Invest 2022 Oct 17;132(20):e157917

4.?Ma C, He D, Tian P, Wang Y, He Y, Wu Q, Jia Z, Zhang X, Zhang P, Ying H, Jin ZB, Hu G*. miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression. Proc Natl Acad Sci U S A 2022 Feb 8;119(6):e2114006119

5.?Xiao Y#, Cong M#, Li J, He D, Wu Q, Tian P, Wang Y, Yang S, Liang C, Liang Y, Wen J, Liu Y, Luo W, Lv X, He Y, Cheng DD, Zhou T, Zhao W, Zhang P, Zhang X, Xiao Y, Qian Y, Wang H, Gao Q, Yang QC, Yang Q, Hu G*. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 2021 Mar 8;39(3):423-437.e7

6.?Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020 Sep 14;54(5):593-607

7.?Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T*, Hu G*. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Nat Commun 2020 May 19;11(1):2487

8.?Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H*, Hu R*, Hu G*. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nat Cancer 2020 Jan 20;1(2):222-234

9.?Ma Q, Wu K, Li H, Li H, Zhu Y, Hu G, Hu L, Kong X. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep 2019 Dec 27;9(1):20021

10.?Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol 2017 Oct;19(10):1274-1285

11.?Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res 2017 Nov 1;77(21):5769-5781

12.?Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr 3;127(4):1284-1302

13.?Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 2017 Mar 16;8(3):e2679

14.?Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 2017 Feb 16;36(7):989-998

15.?Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene 2017 Feb 9;36(6):840-849

16.?Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 2016 Dec 20;7:13884

17.?Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 2016 Dec 1;7(12):e2508

18.?Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res 2015 Sep 1;75(17):3672-3680

19.?Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 2015 Mar 5;13:45

20.?Wei Q,Lei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 2015 Jan;6(1):2-9

21.?Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 2014 Sep 15;74(18):5336-5347

22.?Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 2014 Jun 12;33(24):3119-3128

23.?WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 2014 Apr;124(4):1646-1659

24.?Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem 2013 Mar 29;288(13):9396-9407

25.?Lei R#,Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 2014 Mar 6;33(10):1287-1296

26.?Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 2014 Feb 28;9(2):e90215

27.?Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J Biol Chem 2012 Sep 28;287(40):33533-33544

28.?Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res 2012 Sep;22(9):1356-1373

29.?Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem 2011 Dec 23;286(51):43735-43747

30.?Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer 2011 Nov;2(4):143-148

31.?Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011 Aug 7;17(9):1101-1108

32.?Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. Adv Funct Mater 2011 May 5;21(13):2488-2495

33.?Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res 2010 May 15;70(10):3905-3914

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